Hepatitis E Pathogenesis

Hepatitis E Virus Infection: Pathogenesis and Therapy

Hepatitis E Virus Mutations: Functional and Clinical Relevance

Hepatitis E virus (HEV) infection is a major cause of acute hepatitis and affects more than 20 million individuals, with three million symptomatic cases and 56,000 recognized HEV-related deaths worldwide. HEV is endemic in developing countries and is gaining importance in developed countries, due to increased number of autochthone cases. Although HEV replication is controlled by the host immune...

Quantitative proteomics identifies host factors modulated during acute hepatitis E virus infection in the swine model.

UNLABELLED Hepatitis E virus (HEV) causes acute enterically transmitted hepatitis. In industrialized countries, it is a zoonotic disease, with swine being the major reservoir of human HEV contamination. The occurrence and severity of the disease are variable, with clinical symptoms ranging from asymptomatic to self-limiting acute hepatitis, chronic infection, or fulminant hepatitis. In the abse...

Cloning and expression of hepatitis E virus ORF2 as a vaccine candidate

Introduction: Hepatitis E virus (HEV) is a fecal-oral transmitting virus which causes a chronic liver disease. ORF2 is an immunogen capsid protein of HEV that has been proposed to be used for Hepatitis E vaccine design. It is a 660-amino acid protein which includes an immunogenic region (residues 112-607). This protein has been expressed in complete and truncated forms, using different expressi...

سرواپیدمیولوژی هپاتیت E در عقب‌ماندگان ذهنی شهرستان بیرجند در سال 1396

Background and Aim: Hepatitis E is a viral disease transmitted through contaminated water, which is most commonly reported as an epidemic. Mental retardation among high-risk groups are at high risk of infection, Therefore, the present study was designed and conducted to evaluate the seroepidemiology of hepatitis E in mentally retarded individuals. Materials and Methods: This cross-sectional de...